Discontinuing weight-loss injections can have various outcomes concerning maintaining weight loss. Individuals who have achieved their target weight often consider how their bodies respond after stopping such treatments. The process involves biological, behavioral, and environmental factors that contribute to weight stability or regain. Data indicates that some patients maintain their weight loss with lifestyle modifications, while others may experience weight regain over time. The likelihood of maintaining weight loss post-treatment varies depending on individual adherence to dietary guidelines, physical activity levels, and metabolic factors. Medical professionals generally recommend a comprehensive approach that includes dietary management, exercise, and behavioral therapy to support sustained weight control after discontinuation of injections. Continued monitoring and personalized strategies are key components in managing long-term outcomes after stopping weight-loss pharmacotherapy.